What Happens to Your Blood When You Retire from Alcohol: My 4-Month Lab Results

I want to show you something most people in this space won't show you. Not a before-and-after photo. Not a story about how I feel. Numbers. Actual lab numbers from before I retired from alcohol and four months after.

I retired from alcohol on April 16, 2025. I'm a 51-year-old enterprise sales executive. I spent 30 years as a social drinker. Three to four nights a week for the last decade. Happy hours. Breweries with my wife on Sundays. Wine with dinner. The kind of drinking that looks completely normal from the outside. I got labs done in December 2024, four months before I retired. Then again in August 2025, four months after. Here's what changed.

What did the numbers actually show?

In the four months after I retired from alcohol, my LDL cholesterol dropped 29% (from 212 to 142) and my hs-CRP inflammation marker fell from 2.9 to 1.6, with no new diet, supplements, or medication.

Four months. One change. No new diet. No new supplements. No weight loss program. I retired from alcohol and the body started doing what bodies do when you stop poisoning them.

What does each number actually mean?

LDL dropped 29%, from 212 to 142. Mine was elevated enough that my doctor had mentioned statins more than once. I kept pushing it off. Four months after retiring from alcohol, it was 142. Still not perfect, but trending the right direction without a single pill. Alcohol raises LDL through multiple pathways. It increases the liver's production of VLDL particles, which convert to LDL. It also impairs the liver's ability to clear LDL from the bloodstream. Remove the alcohol and both mechanisms improve.

LDL: 212 before. 142 after. 29% reduction in four months. No medication. No diet change. One variable.

Inflammation cut nearly in half, from 2.9 to 1.6. hs-CRP measures systemic inflammation. Anything above 3.0 is considered high cardiovascular risk. I was at 2.9, right at the edge. Alcohol is a direct inflammatory agent. Every drink triggers an inflammatory response. Do that four nights a week for ten years and it stacks up.

Two medications gone. I had been on amlodipine for blood pressure since my mid-30s. I told myself it was hereditary. But alcohol raises blood pressure through multiple mechanisms. I had also been on omeprazole for acid reflux for years. My esophagus was inflamed enough that I ended up in the emergency room in 2020. They had to put me under and have a surgeon clear my throat to dislodge a piece of steak stuck in scarring from chronic reflux. I kept drinking after that. As of February 2026, I'm off both medications. Blood pressure is better than it was on the medication. No acid reflux.

Liver enzymes normalized. AST dropped from 20 to 14. ALT dropped from 26 to 20. Both were within normal range before, but at the high end. Now they're comfortably in range. The liver is remarkably good at recovering when you give it the chance.

The HDL drop. HDL went from 50 to 38. That's the one number that moved the wrong direction. I'm not going to hide it. This is a documented phenomenon after stopping alcohol. Alcohol artificially raises HDL, so when you stop, it drops. The research suggests this is temporary and that long-term sobriety tends to bring it back up. The net cardiovascular picture is still dramatically better. LDL down 29%, inflammation nearly halved, two medications gone. The HDL drop is worth monitoring, not worth worrying about.

What else changed besides stopping drinking?

This is the part worth emphasizing. I didn't start a new diet. I didn't add supplements. I actually removed 25 supplements I had been taking to mask the effects of drinking. I didn't hire a trainer or change my workout routine. I've lifted since I was 15 and that didn't change. The only variable that changed was alcohol.

I also lost 14 pounds in the first four months. Not from dieting. From eliminating the caloric load of regular drinking, reducing the inflammation that causes water retention, and sleeping better, which improved body composition on its own.

How long did it take?

The meaningful changes showed up within four months. That's not a long time. Sleep took longer. Close to a full year to fully stabilize. The first few months were rough. The body is used to using alcohol to fall asleep and it takes time to relearn. Cognitively, the shift was faster than I expected. Within weeks I was sharper on strategy calls. More patient. Thinking three moves ahead instead of reacting. My VP of sales started calling nightly to work through deals. My management team noticed before I said anything.

Why publish these numbers?

Most sobriety content is built around emotion. Rock bottoms. Dramatic loss. I didn't have any of that. I was a high-functioning professional who drank socially and spent six years quietly thinking about what life could look like without alcohol before I actually made the decision. No crisis. No label. A deliberate retirement on a specific date.

The lab data is what I wish someone had shown me during those six years. Not to scare me. To give me something concrete. To make the case in a language I understand: numbers, outcomes, data. If you've been thinking about this for a while and you're not sure whether your drinking is actually affecting your health, it probably is. Not dramatically. Quietly. The way a slow leak drains a tire. The good news is the body responds fast when you give it the chance.

Colin Casillas founded Prepared Sobriety to help high-earning professionals retire from alcohol on their own terms. He retired on April 16, 2025 after 30 years of regular drinking. His LDL dropped 29%, he lost 14 lbs, both within his first four months, and two medications were eliminated within his first ten months. If you're ready to make a deliberate exit, work with Colin directly.